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Application progress of lymphography in oncology

Yang YU, Jibin LIU, Lixue YIN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 13-19 doi: 10.1007/s11684-009-0016-7

Abstract: Lymphography is often used for the diagnosis of lymphatic metastasis in oncology. Determination of lymphatic metastasis is extremely important for accurate cancer staging, which may directly guide the clinical therapeutic scheme. In recent years, the technology of lymphography has developed rapidly on the basis of traditional lymphography, with the appearance of computed tomography (CT) lymphography, nuclear magnetic resonance (MR) lymphography, contrast-enhanced lymphosonography, and so on; the diagnostic accuracy has also been improved. The imaging principles and methods of these various technologies of lymphography are reviewed in this paper, and their applications and significance in oncology are also discussed in detail.

Keywords： lymphography     lymphatic metastasis     sentinel lymph node biopsy    

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Clinical significance of para-aortic lymph node dissection and prognosis in ovarian cancer

Xianxian Li, Hui Xing, Lin Li, Yanli Huang, Min Zhou, Qiong Liu, Xiaomin Qin, Min He

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 96-100 doi: 10.1007/s11684-014-0316-4

Abstract:

Lymph node metastasis has an important effect on prognosis of patients with ovarian cancer.Moreover, the impact of para-aortic lymph node (PAN) removal on patient prognosis is still unclear.Group A consisted of 30 patients who underwent PAN+ pelvic lymph node (PLN) dissection, whereas groupIn group B, 13 cases were positive for lymph node metastasis.Our study suggested that the metastatic rate of lymph node is 40.0%.

Keywords： ovarian cancer     para-aortic lymph node     pelvic lymph node    

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The value of ultrasound elastography in differential diagnosis of superficial lymph nodes

Yanrong ZHANG phD , Qing LV MD , Mingxing XIE MD , Feixiang XIANG phD , Chengfa LU BM , Tianwei YAN BM , Wei LI BM , Hui XU BM , Yan HUANG BM , Yehua YIN BM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 368-374 doi: 10.1007/s11684-009-0063-0

Abstract: evaluated the value of ultrasound elastography in differentiating the benign and malignant superficial lymphA total of 112 subjects, including 82 patients with enlarged lymph nodes and 30 healthy volunteers, wereThe elasticity of the lymph nodes was quantitatively measured and defined as stiffness value.The stiffness values of two indeterminate benign lymph nodes, the elastrographic findings of which wereThe elastographic findings of 10 malignant lymph nodes were also classified as pattern 2 or 3.

Keywords： ultrasound elastography     lymph node     power Doppler sonography    

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Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervical cancer

Tian Wang, Yan Li, Abidan Tuerhanjiang, Wenwen Wang, Zhangying Wu, Ming Yuan, Shixuan Wang

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 106-112 doi: 10.1007/s11684-014-0307-5

Abstract:

Cervical carcinoma is associated with high propensity for local invasion and lymph node metastasisThe strong positive expressions of Twist in the SCC groups with or without lymph node metastasis were

Keywords： cervical cancer     senescence     Twist     CBX3     lymph node metastasis    

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Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer: a randomized, non-inferiority, multicenter trial

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 93-104 doi: 10.1007/s11684-021-0892-z

Abstract: We conducted a prospective study to assess the non-inferiority of adjuvant chemotherapy alone versus adjuvant concurrent chemoradiotherapy (CCRT) as an alternative strategy for patients with early-stage (FIGO 2009 stage IB–IIA) cervical cancer having risk factors after surgery. The condition was assessed in terms of prognosis, adverse effects, and quality of life. This randomized trial involved nine centers across China. Eligible patients were randomized to receive adjuvant chemotherapy or CCRT after surgery. The primary end-point was progression-free survival (PFS). From December 2012 to December 2014, 337 patients were subjected to randomization. Final analysis included 329 patients, including 165 in the adjuvant chemotherapy group and 164 in the adjuvant CCRT group. The median follow-up was 72.1 months. The three-year PFS rates were both 91.9%, and the five-year OS was 90.6% versus 90.0% in adjuvant chemotherapy and CCRT groups, respectively. No significant differences were observed in the PFS or OS between groups. The adjusted HR for PFS was 0.854 (95% confidence interval 0.415–1.757; P = 0.667) favoring adjuvant chemotherapy, excluding the predefined non-inferiority boundary of 1.9. The chemotherapy group showed a tendency toward good quality of life. In comparison with post-operative adjuvant CCRT, adjuvant chemotherapy treatment showed non-inferior efficacy in patients with early-stage cervical cancer having pathological risk factors. Adjuvant chemotherapy alone is a favorable alternative post-operative treatment.

Keywords： chemotherapy     cervical cancer     lymph node metastasis     concurrent chemoradiotherapy     quality of life    

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Design and evaluation of a novel biopsy needle with hemostatic function

Frontiers of Mechanical Engineering 2023, Volume 18, Issue 2, doi: 10.1007/s11465-022-0738-7

Abstract: Biopsy is a method commonly used for early cancer diagnosis.However, bleeding complications of widely available biopsy are risky for patients.Safer biopsy will result in a more accurate cancer diagnosis and a decrease in the risk of complicationsIn this article, we propose a novel biopsy needle that can reduce bleeding during biopsy procedures andThe proposed biopsy needle features a compact structure and can be operated easily by left and right

Keywords： cancer diagnosis     biopsy needle     hemostatic function     predictive model     coupled Eulerian−Lagrangian    

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Clinical characteristics and outcomes of biopsy-proven diabetic nephropathy

Li Zhuo, Nianrong Zhang, Guming Zou, Dapeng Chen, Wenge Li

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 386-392 doi: 10.1007/s11684-017-0574-z

Abstract: In this study, the clinical manifestations of 111 cases of biopsy-proven DN were described, and the clinicalIn conclusion, the clinical characteristics of DN vary, and renal biopsy is necessary to determine renal

Keywords： diabetic nephropathy     clinical characteristics     renal biopsy     outcomes    

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Application of liquid biopsy in precision medicine: opportunities and challenges

Junyun Wang, Shuang Chang, Guochao Li, Yingli Sun

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 522-527 doi: 10.1007/s11684-017-0526-7

Abstract: circulating tumor cell (CTC) or circulating tumor DNA (ctDNA) in plasma or serum could serve as liquid biopsy

Keywords： liquid biopsy     circulating tumor cells     cell-free ctDNA     exosomes     precision medicine    

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Utility of transbronchial biopsy in the diagnosis of lymphangioleiomyomatosis

Riffat Meraj, Kathryn A. Wikenheiser-Brokamp, Lisa R. Young, Sue Byrnes, Francis X. McCormack

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 395-405 doi: 10.1007/s11684-012-0231-5

Abstract: Although surgical lung biopsy is considered the gold standard for obtaining tissue in patients with diffuseThe objective of our study was to examine the utility of transbronchial biopsy in the diagnosis of LAMTransbronchial biopsy specimens were subsequently collected and reviewed by an expert pathologist toWe found that transbronchial biopsy has a yield of approximately 60% in patients with LAM.of LAM, obviating the need for surgical lung biopsy in more than half of LAM patients.

Keywords： lymphangioleiomyomatosis     lymphangiomyomatosis     multicystic lung disease     diffuse cystic lung disease     transbronchial biopsy    

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Spatial embedded reinforcement of 20-node block element for analysis PC bridges

LONG Peiheng, DU Xianting, CHEN Weizhen

Frontiers of Structural and Civil Engineering 2008, Volume 2, Issue 3,   Pages 274-280 doi: 10.1007/s11709-008-0039-1

Abstract: It is an effective approach that the no-node loads are diverted from the tendons to the adjacent concrete

Keywords： arithmetic analysis     calculation     prestressed reinforcement     mechanical     arbitrary    

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Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breastcancer was similar in node-negative diseases: a single-center study of 800 patients

Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 621-628 doi: 10.1007/s11684-020-0738-0

Abstract: Multi-gene assays have emerged as crucial tools for risk stratification in early-stage breast cancer. This study aimed to evaluate the prognostic significance of the 21-gene recurrence score (RS) in Chinese patients with pN0-1, estrogen receptor-positive (ER ), human epidermal growth factor receptor 2-negative (HER2 ) breast cancer. Among 800 patients recruited between 2009 and 2016, the median RS was 24 (0–69), with 27.4%, 46.8%, and 25.9% patients classified into low-, intermediate-, and high-risk groups. Cox regression analysis demonstrated that the high-risk category was associated with significantly higher odds of invasive disease-free survival (IDFS) and distant disease-free survival (DDFS) events compared with the low-risk category (IDFS: HR= 2.450, 95% CI 1.017–5.902, = 0.046; DDFS: HR= 2.829, 95% CI 1.013–7.901, = 0.047). No significant association between RS category and overall survival (OS) was found (intermediate vs. low: HR= 1.244, 95% CI 0.292–5.297, = 0.768; high vs. low: HR= 2.933, 95% CI 0.759–11.327, = 0.119). RS, as a continuous variable, was a highly significant predictor for IDFS (HR= 1.028, 95% CI 1.010–1.047, = 0.002), DDFS (HR= 1.030, 95% CI 1.010–1.051, = 0.003), and OS (HR= 1.034, 95% CI 1.007–1.063, = 0.014). Our findings suggested that RS may predict IDFS in Chinese patients with ER /HER2 breast cancer with N0 or N1 disease.

Keywords： early breast cancer     21-gene assay     recurrence score     prognosis    

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Study on road network model based on virtual node joint

Zhu Zhuangsheng,Wang Qing,Wan Dejun

Strategic Study of CAE 2009, Volume 11, Issue 8,   Pages 83-87

Abstract: text-align: justify;">The road network in the real world has been showed by the road network model based on nodeIt is the first time that a novel road network model,that is,the road network model based on virtual nodeThe novel model adops virtual node to show multi-road converging area,and the virtual node is an areaThe novel model has better of image the traffic flow on the road network than the old model based on node

Keywords： traffic engineering     virtual node     road network model     map matching     transportation planning    

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ECRG4: a new potential target in precision medicine

Xin Qin, Ping Zhang

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 540-546 doi: 10.1007/s11684-018-0637-9

Abstract: cancer-related gene-4 ( ), which is initially known as a new candidate tumor suppressor gene, is emerging as a sentinelThe gene can be released from the cell membrane upon activation and detected in liquid biopsy, thus offering

Keywords： ECRG4     tumor suppressor gene     sentinel molecule     precision medicine     cell senescence     epithelium homeostasis    

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Node Status Monitoring of Information-Centric Internet of Things

Cui Liqun, Wu Jun

Strategic Study of CAE 2020, Volume 22, Issue 6,   Pages 121-127 doi: 10.15302/J-SSCAE-2020.06.016

Abstract: network status information of the information-centric Internet of Things (IC-IoT), this study proposes a nodeIt first proposes a new management information base structure for recording various network node statusthe naming format of information-centric networking (ICN), centering on the content of the network node

Keywords： information-centric networking，Internet of Things，node status monitoring，access control    

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Simulation of cohesive crack growth by a variable-node XFEM

Weihua FANG, Jiangfei WU, Tiantang YU, Thanh-Tung NGUYEN, Tinh Quoc BUI

Frontiers of Structural and Civil Engineering 2020, Volume 14, Issue 1,   Pages 215-228 doi: 10.1007/s11709-019-0595-6

Abstract: new computational approach that combines the extended finite element method associated with variable-nodeBy using a new enriched technique based on sign function, the proposed model using 4-node quadrilateralThe multiscale mesh technique associated with variable-node elements and the arc-length method further

Keywords： extended finite element method     cohesive zone model     sign function     crack propagation    

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Title Author Date Type Operation

Application progress of lymphography in oncology

Yang YU, Jibin LIU, Lixue YIN

Journal Article

Clinical significance of para-aortic lymph node dissection and prognosis in ovarian cancer

Xianxian Li, Hui Xing, Lin Li, Yanli Huang, Min Zhou, Qiong Liu, Xiaomin Qin, Min He

Journal Article

The value of ultrasound elastography in differential diagnosis of superficial lymph nodes

Yanrong ZHANG phD , Qing LV MD , Mingxing XIE MD , Feixiang XIANG phD , Chengfa LU BM , Tianwei YAN BM , Wei LI BM , Hui XU BM , Yan HUANG BM , Yehua YIN BM ,

Journal Article

Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervical cancer

Tian Wang, Yan Li, Abidan Tuerhanjiang, Wenwen Wang, Zhangying Wu, Ming Yuan, Shixuan Wang

Journal Article

Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer: a randomized, non-inferiority, multicenter trial

Journal Article

Design and evaluation of a novel biopsy needle with hemostatic function

Journal Article

Clinical characteristics and outcomes of biopsy-proven diabetic nephropathy

Li Zhuo, Nianrong Zhang, Guming Zou, Dapeng Chen, Wenge Li

Journal Article

Application of liquid biopsy in precision medicine: opportunities and challenges

Junyun Wang, Shuang Chang, Guochao Li, Yingli Sun

Journal Article

Utility of transbronchial biopsy in the diagnosis of lymphangioleiomyomatosis

Riffat Meraj, Kathryn A. Wikenheiser-Brokamp, Lisa R. Young, Sue Byrnes, Francis X. McCormack

Journal Article

Spatial embedded reinforcement of 20-node block element for analysis PC bridges

LONG Peiheng, DU Xianting, CHEN Weizhen

Journal Article

Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breastcancer was similar in node-negative diseases: a single-center study of 800 patients

Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen

Journal Article

Study on road network model based on virtual node joint

Zhu Zhuangsheng,Wang Qing,Wan Dejun

Journal Article

ECRG4: a new potential target in precision medicine

Xin Qin, Ping Zhang

Journal Article

Node Status Monitoring of Information-Centric Internet of Things

Cui Liqun, Wu Jun

Journal Article

Simulation of cohesive crack growth by a variable-node XFEM

Weihua FANG, Jiangfei WU, Tiantang YU, Thanh-Tung NGUYEN, Tinh Quoc BUI

Journal Article